emirates7 - A research team from the University of Leicester, in collaboration with scientists from the University of Copenhagen and Queen Mary University of London, has carried out the first-ever genetic investigation into chronic cough. Their groundbreaking findings were recently published in the European Respiratory Journal.

The study analyzed data from nearly 30,000 people suffering from chronic cough, drawn from several large-scale population health resources, including the UK Biobank, EXCEED Study, Copenhagen Hospital Biobank, Genes & Health, and the eMERGE Network.

As the most comprehensive and diverse genetic study of chronic cough to date, the researchers identified genes linked to neuronal signaling and sensory pathways—highlighting a neurological component to the condition.

These findings enhance the understanding of cough reflex hypersensitivity as a process governed by the nervous system and pave the way for the development of more targeted therapies.

The study also discovered genetic overlaps between chronic cough and chronic pain, pointing to common neurological pathways. This breakthrough offers a strong basis for future research and may support the development of better management strategies for both conditions.

Dr. Kayesha Coley, the lead researcher from the University of Leicester’s Genetic Epidemiology group, stated that the study marks a significant advancement in understanding the biological mechanisms behind chronic cough and has the potential to guide future drug development.

Chronic cough can drastically reduce quality of life, leading to symptoms such as fatigue, shortness of breath, disrupted sleep, and emotional strain. For many individuals, it becomes a debilitating issue that interferes with daily life and social activities.